Bisabolol

The calming part of chamomile, on its own — it softens the look of redness, and over weeks helps even out tone.

On a label you may see
Alpha-bisabolol and Levomenol

Last reviewed August 7, 2026 · 29 sources, 9 of them regulators or official bodies · how we check this

Best time
Morning or evening
How often
Daily
Strength
Gentle
Sun sensitivity
None

Where to apply

All over the face

Never in your eyes or on your lips.

What does Bisabolol do?#

A soothing serum with bisabolol, a naturally derived compound found in chamomile, that helps visibly calm redness and supports a more comfortable-looking complexion.

  • Helps calm the appearance of redness and irritation
  • Supports a more comfortable, even-looking skin tone
  • Lightweight serum absorbs easily without heaviness

How it works

Bisabolol is a naturally derived compound found in chamomile. It helps skin look calmer and more comfortable, and contributes to a more even-looking skin tone.

How to use Bisabolol#

  • Every day, morning or evening. There is nothing to ease into and no settling-in period to wait out — a full amount is fine from the first day.
  • In routine order: a serum goes on after cleansing and toning, a cream goes on last.
  • Across the whole face. Smooth it on rather than rubbing it in.
  • It shares a routine comfortably with everything else on the shelf, exfoliants and retinoids included, so it never needs an evening of its own.
  • Bisabolol does not make skin more sensitive to sunlight, so it asks nothing beyond your usual sunscreen — though daily sun protection is what lets the evening-out of tone show at all.
  • Bisabolol comes from the same plant family as daisies, chamomile, feverfew and arnica. If you already react to any of those, patch test before the first full use.
  • If skin does react, stop rather than push through. This is not an ingredient that stings on the way to suiting you, so a reaction will not settle with time.

Discontinue use if irritation occurs. Those with chamomile or Compositae/Asteraceae family allergies should patch test first.

Forms you will see it in

Chamomile calming serum

Where it goes
Before moisturizer, morning or evening
How often
Daily
Strength
Gentle
Sun sensitivity
None

Chamomile cream

Where it goes
As your moisturizer, morning or evening
How often
Daily
Strength
Gentle
Sun sensitivity
None

Using Bisabolol with other ingredients

Pairs well with Bisabolol

Niacinamide

Works well together

Complementary calming benefits for visibly soothed skin.

Panthenol (B5)

Works well together

Both support skin comfort and a healthier-looking complexion.

Allantoin

Works well together

Both contribute to a calmer, more comfortable-looking complexion.

What not to use with Bisabolol

Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Bisabolol — check the label of anything not covered here.

Who should avoid Bisabolol?#

Six situations change whether Bisabolol suits your skin right now. Each one is either a reason to skip it, a reason to go slowly, or nothing to watch for.

Maternity & Nursing
Go slowly
Dry or Itchy Patches
Go slowly
Fragile or Sensitive
No caution
Recent Facial or Laser
No caution
Prone to Redness
No caution
Recent Shave or Wax
No caution

Maternity & NursingIf you are pregnant or nursing, you may prefer to check with your healthcare provider before use.

Dry or Itchy PatchesKeep the rest of your routine well moisturized, and use it less often — or stop — if you notice tightness or itching.

Cosmetic strength limits for Bisabolol where you live#

RegionMaximum strength
United StatesNo explicit cap
CanadaNo explicit cap
European UnionNo explicit cap
Great BritainNo explicit cap

No cosmetic regulator in these four markets sets a maximum strength for bisabolol. That is a limit on the rules, not a signal to use more: how much goes into a product is the formulator's decision.

Products with Bisabolol#

We may earn a small commission when you buy through these links.

Common questions about Bisabolol#

When should you apply Bisabolol?

Every day, morning or evening. There is nothing to ease into and no settling-in period to wait out — a full amount is fine from the first day.

Which form of Bisabolol should you use?

Chamomile calming serum — before moisturizer, morning or evening, daily. Chamomile cream — as your moisturizer, morning or evening, daily.

How often can you use Bisabolol?

Daily.

Where do you apply Bisabolol?

All over the face. Keep it away from your eyes and lips.

Does Bisabolol make skin more sensitive to the sun?

No. Bisabolol is not flagged as increasing sun sensitivity.

What should you not use with Bisabolol?

Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Bisabolol — check the label of anything not covered here.

Who should avoid Bisabolol?

Go slowly with Maternity & Nursing and Dry or Itchy Patches.

Is there a cosmetic limit for Bisabolol?

No. No cosmetic regulator in the United States, Canada, the European Union or Great Britain sets a maximum strength for it. That is a limit on the rules, not a signal to use more.

How we check this#

Everything on this page traces to the sources listed below — regulators' own publications and published studies. Where the evidence does not answer a question, it is left unanswered.

Some sources below are the official product information for prescription medicines — some contain this ingredient at higher strengths, others are cited for how they interact with it. We use them for their safety and handling detail only. A cosmetic product is not one of those medicines and is not intended to treat any condition.

Our review is AI-assisted and is not a named expert's opinion. Last reviewed August 7, 2026.

Think something here is out of date or wrong? Email us at wiki@skinintelligence.ai with your reasoning and where you read it. We read what people send, and we update the page when the sources support it.

Regulators and official bodies · 9

  1. S1Cosmetic Ingredient Review. Safety Assessment of Bisabolol as Used in Cosmetics — Re-Review for Panel Review. Release 20 Feb 2015; Panel meeting 17–18 Mar 2015; prepared by Monice M. Fiume. Includes the 1999 Final Report Summary and Discussion and the 1994–1997 Panel minutes.
  2. S14Regulation (EU) 2023/1545 amending Regulation (EC) No 1223/2009 as regards labelling of fragrance allergens in cosmetic products. OJ L 188, 27.7.2023. CELEX 32023R1545.
  3. S15Regulation (EC) No 1223/2009 on cosmetic products, Annexes II and III, as retained in UK law. legislation.gov.uk/eur/2009/1223/annex/II and /annex/III.
  4. S16Health Canada. Cosmetic Ingredient Hotlist: List of Ingredients that are Prohibited for Use in Cosmetic Products..
  5. S17US Food and Drug Administration. Prohibited & Restricted Ingredients in Cosmetics..
  6. S18European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Matricaria recutita L., flos. EMA/HMPC/55843/2011. Chamomile flower preparations, not isolated bisabolol..
  7. S23Isotretinoin 10 mg soft capsules — Summary of Product Characteristics, §4.4 and §4.5. MHRA-authorised product information via the electronic Medicines Compendium.
  8. S24Adapalene/Benzoyl Peroxide 0.1%/2.5% gel — Summary of Product Characteristics, §4.4 and §4.5. MHRA-authorised product information via the electronic Medicines Compendium.
  9. S25Cosmetic Ingredient Review. Safety Assessment of Chamomilla Recutita-Derived Ingredients as Used in Cosmetics (final report, 2014), including Table 1, "Data from CIR Final Safety Assessment on Bisabolol".

Studies and references · 20

  1. S2Andersen F, Hedegaard K, Petersen TK, Bindslev-Jensen C, Fullerton A, Andersen KE. Anti-irritants I: Dose-response in acute irritation. Contact Dermatitis. 2006;55(3):148–154. PMID 16918613. doi:10.1111/j.1600-0536.2006.00752.x.
  2. S3Andersen F, Hedegaard K, Petersen TK, Bindslev-Jensen C, Fullerton A, Andersen KE. Anti-irritants II: Efficacy against cumulative irritation. Contact Dermatitis. 2006;55(3):155–159. PMID 16918614. doi:10.1111/j.1600-0536.2006.00756.x.
  3. S4Ying Y, Fang Y, Chenlan X, Lin S, Jiefang H, Yanan L, Peiwen S. Evaluating the Efficacy of Soothing Agents in Mitigating 0.1% Retinol-Induced Skin Irritation: A Patch Test. J Cosmet Dermatol. 2025;24(10):e70488. PMID 41044804; PMC12494960. doi:10.1111/jocd.70488.
  4. S5Andersen F, Hedegaard K, Petersen TK, Bindslev-Jensen C, Fullerton A, Andersen KE. The hairless guinea-pig as a model for treatment of cumulative irritation in humans. Skin Res Technol. 2006;12(1):60–67. PMID 16420540. doi:10.1111/j.0909-725X.2006.00133.x.
  5. S6Andersen F, Hedegaard K, Fullerton A, Petersen TK, Bindslev-Jensen C, Andersen KE. The hairless guinea-pig as a model for treatment of acute irritation in humans. Skin Res Technol. 2006;12(3):183–189. PMID 16827693. doi:10.1111/j.0909-752X.2006.00148.x.
  6. S7Jacob SE, Matiz C, Herro EM. Compositae-associated allergic contact dermatitis from bisabolol. Dermatitis. 2011;22(2):102–105. PMID 21504695. doi:10.2310/6620.2011.10118.
  7. S8Russell K, Jacob SE. Bisabolol. Dermatitis. 2010;21(1):57–58. PMID 20137740.
  8. S9Pastor N, Silvestre JF, Mataix J, Lucas A, Pérez M. Contact cheilitis from bisabolol and polyvinylpyrrolidone/hexadecene copolymer in lipstick. Contact Dermatitis. 2008;58(3):178–179. PMID 18279165. doi:10.1111/j.1600-0536.2007.01225.x.
  9. S10Hausen BM. A 6-year experience with compositae mix. Am J Contact Dermat. 1996;7(2):94–99. PMID 8796749. doi:10.1016/s1046-199x(96)90081-0.
  10. S11Paulsen E, Andersen KE, Hausen BM. An 8-year experience with routine SL mix patch testing supplemented with Compositae mix in Denmark. Contact Dermatitis. 2001;45(1):29–35. PMID 11422265. doi:10.1034/j.1600-0536.2001.045001029.x.
  11. S12Kadir R, Barry BW. α-Bisabolol, a possible safe penetration enhancer for dermal and transdermal therapeutics. Int J Pharm. 1991;70(1–2):87–94. doi:10.1016/0378-5173(91)90167-M — authorship confirmed via Crossref; the ScienceDirect capture held in the vault lists only Barry.
  12. S13Lee J, Jun H, Jung E, Ha J, Park D. Whitening effect of alpha-bisabolol in Asian women subjects. Int J Cosmet Sci. 2010;32(4):299–303. PMID 20642768. doi:10.1111/j.1468-2494.2010.00560.x.
  13. S19Bjerring P, Draelos ZD, Fabi SG, Goodman GJ, Hau KC, Haus A, Heydenrych I, Kim J, Lin LC, Sayed K, Sundaram H, Tsubouchi R, Wu Y, Brieva P, Choudhary H, Xiang LF. International Expert Consensus on Integrated Skincare Active Ingredients for Pretreatment and Posttreatment Use With Medical Aesthetic Procedures to Enhance Skin Benefits. J Cosmet Dermatol. 2026;25:e70880. PMID 42087526; PMC13145317. doi:10.1111/jocd.70880.
  14. S20Nikolis A, Nestor MS, Czuwara J, Depfenhart M, Fluhr JW, Addor FASA, Piotrowski K, Zielinski Y, Lachmann N, Prygova I, Berlin I, Pellacani G. Concomitant Use of Dermo-Cosmetic Skin Care in Aesthetic Procedures: Systematic Review with Expert Panel Recommendations. Clin Cosmet Investig Dermatol. 2026;19. PMID 41773167; PMC12949975. doi:10.2147/CCID.S577128.
  15. S21Somboon K, Chng CP, Huang C, Gupta S. Enhancing Niacinamide Skin Penetration via Other Skin Brightening Agents: A Molecular Dynamics Simulation Study. Int J Mol Sci. 2025;26(4):1555. PMID 40004021. doi:10.3390/ijms26041555 — in silico.
  16. S22Maurya AK, Singh M, Singh M, Dubey V, Srivastava S, Luqman S, Bawankule DU. α-(−)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. Curr Pharm Biotechnol. 2014;15(2):173–181. PMID 24894548. doi:10.2174/1389201015666140528152946 — in vitro + mouse.
  17. S26Vanessa VV, Wan Ahmad Kammal WSL, Lai ZW, How KN. A Review of Moisturizing Additives for Atopic Dermatitis. Cosmetics. 2022;9(4):75. doi:10.3390/cosmetics9040075 — cited only for its Compositae-prevalence secondary reporting; note that this review states bisabolol dermocosmetics "have shown soothing effects" on the strength of multi-ingredient products and does not cite [2][3].
  18. S27He M, Zhou P, Chen H, Zhang J, Zhang Y, Zheng X, Zhu W, Han L. (−)-α-Bisabolol inhibits D-Gal-induced HSF cellular senescence in vitro and prevents skin aging. Iran J Basic Med Sci. 2024;27(9):1105–1114. PMID 39055870. doi:10.22038/ijbms.2024.76073.16469 — in vitro + mouse.
  19. S28Licari A, Ruffinazzi G, De Filippo M, Castagnoli R, Marseglia A, Agostinis F, Puviani M, Milani M, Marseglia GL. A starch, glycyrretinic, zinc oxide and bisabolol based cream in the treatment of chronic mild-to-moderate atopic dermatitis in children: a three-center, assessor blinded trial. Minerva Pediatr. 2017;69(6):470–475. PMID 29181960. doi:10.23736/S0026-4946.17.05015-0 — multi-ingredient, uncontrolled.
  20. S29Varothai S, Chaweekulrat P, Pruksaeakanan C, Wongdama S, Boonchai W. Efficacy of panthenol- and bisabolol-containing lip care as monotherapy for mild-to-moderate cheilitis. Int J Dent Hyg. 2024;22(4):711–716. PMID 37877137. doi:10.1111/idh.12779 — multi-ingredient, open-label, no control.

Cosmetic guidance only. Skin Intelligence is a cosmetic skincare tool, not a medical device, and does not diagnose, treat, cure, or prevent any condition. Always follow the directions on the product you are using — where they differ from anything on this page, the label takes precedence. If you have a skin concern, please see a healthcare professional.

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