What does Ferments / Probiotics do?#
Fermented skincare ingredients contain beneficial byproducts from bacteria and yeast fermentation, including peptides, polysaccharides and organic acids that help skin hold on to moisture and feel comfortable.
- Helps skin hold on to moisture for a hydrated, comfortable feel
- Helps the skin surface look calmer, smoother and more even
- Provides gentle, comforting support suitable for all skin types, including sensitive skin
How it works
Fermented skincare ingredients are the beneficial byproducts of bacterial and yeast fermentation, including peptides, polysaccharides and organic acids that help skin hold on to moisture. These components help support a healthier-looking, more resilient skin surface and help the skin look calmer, smoother and more even in surface texture. They promote a well-conditioned skin surface that looks and feels calm and hydrated.
How to use Ferments / Probiotics#
- Every day. There is nothing to build up to — a full amount is fine from the first day, and the form you have will say whether it belongs to the morning, the evening or both.
- On clean skin, before anything heavier: an essence goes on first, a serum after it and before moisturizer.
- Across the whole face. Press it in rather than rubbing, and it is gentle enough to bring close to the eye area.
- It does not make skin more sensitive to sunlight, so a form used in the morning needs nothing beyond your usual sunscreen.
- It should not sting. If one stings, the alcohol or fragrance in that particular formula is the likelier cause than the ferment itself, so try a different product.
- There is no settling-in period to expect — nothing gets worse first, and what does change builds gradually over weeks.
Fermented skincare ingredients are generally well tolerated. These products contain fermentation byproducts, not live bacteria.
Forms you will see it in
Galactomyces ferment essence
- Where it goes
- After cleansing, morning or evening
- How often
- Daily
- Strength
- Gentle
- Sun sensitivity
- None
Ferment serum
- Where it goes
- Before moisturizer, morning or evening
- How often
- Daily
- Strength
- Gentle
- Sun sensitivity
- None
Using Ferments / Probiotics with other ingredients
Pairs well with Ferments / Probiotics
Panthenol (B5)
Works well togetherBoth are gentle, hydrating steps that sit comfortably together for a calm, well-conditioned feel.
Centella asiatica
Works well togetherFerments help condition the skin surface while centella helps it look calm and comfortable.
Niacinamide
Works well togetherBoth support a healthy-looking moisture barrier through complementary approaches.
What not to use with Ferments / Probiotics
Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Ferments / Probiotics — check the label of anything not covered here.
Who should avoid Ferments / Probiotics?#
Six situations change whether Ferments / Probiotics suits your skin right now. Each one is either a reason to skip it, a reason to go slowly, or nothing to watch for.
- Fragile or Sensitive
- Go slowly
- Recent Facial or Laser
- Go slowly
- Maternity & Nursing
- No caution
- Prone to Redness
- No caution
- Dry or Itchy Patches
- No caution
- Recent Shave or Wax
- No caution
Fragile or Sensitive — Use it less often — or stop — if it feels uncomfortable, and keep it off skin that’s broken, cut or sunburned.
Recent Facial or Laser — Wait until your skin feels settled before reintroducing — typically 7 to 14 days after a facial or laser appointment.
Cosmetic strength limits for Ferments / Probiotics where you live#
| Region | Maximum strength |
|---|---|
| United States | No explicit cap |
| Canada | No explicit cap |
| European Union | No explicit cap |
| Great Britain | No explicit cap |
No cosmetic regulator in these four markets sets a maximum strength for ferments / probiotics. That is a limit on the rules, not a signal to use more: how much goes into a product is the formulator's decision.
Products with Ferments / Probiotics#
We may earn a small commission when you buy through these links.
Galactomyces ferment essence · 19
COSRXGalactomyces 95 Tone Balancing Essence - 100ml$19.20
MISSHATime Revolution The First Treatment Essence 5X - 150ml$30.48
mixsoonGalactomyces Ferment Essence - 100ml$24.00
mixsoonBifida Ferment Essence - 30ml$13.50
mixsoonGalactomyces Toner Pad - 60 pads$19.50
mixsoonBifida Toner - 150ml$11.25
Purito SEOULFermented Complex 94 Boosting Essence - 150ml$15.40
BentonFermentation Essence - 100ml$24.30
Estee LauderMicro Essence Treatment Lotion with Bio-Ferment - 30ml$8.53
Estee LauderMicro Essence Skin Activating Treatment Lotion Fresh with Sakura Fermentt - 200ml$81.14
haruharu wonderBlack Rice Probiotics Barrier Essence (Milky Essence) - 120ml$19.60
Ma:nyoBifida Cica Herb Toner - 210ml$17.10
Ma:nyoBifida Biome Ampoule Toner - 400ml$21.25
NEOGEN DermalogyDermalogy Real Ferment Micro Essence - 150ml$38.00
NEOGEN DermalogyReal Ferment Micro Toner - 150ml$17.60
PRETTYSKINGalactomyces First Essence 14 Days - 150ml$8.88
PRETTYSKINGalactomyces First Essence Pad - 140ml/70ea$8.04
SCINICFirst Treatment Essence - 150ml$12.79
TOCOBOBifida Biome Essence - 50ml$25.20Ferment serum · 7
Cos De BAHAGalactomyces Serum (GN) - 30ml$10.93
IsntreeTW-Real Bifida Ampoule - 50ml$21.76
AbibJericho Rose Bifida Serum Firming Drop - 50ml$25.60
Esthetic HouseEsthetic Formula Ampoule - Galactomyces 97% - 80ml$5.09
L'OREAL PARISYouth Code Skin Activating Ferment Pre-Essence Serum - 30ml$17.58
Ma:nyoBifida Biome Complex Ampoule - 50ml$31.50
NEOGEN DermalogyREAL FERMENT MICRO SERUM - 30ml$30.40Common questions about Ferments / Probiotics#
When should you apply Ferments / Probiotics?
- Every day. There is nothing to build up to — a full amount is fine from the first day, and the form you have will say whether it belongs to the morning, the evening or both.
Which form of Ferments / Probiotics should you use?
- Galactomyces ferment essence — after cleansing, morning or evening, daily. Ferment serum — before moisturizer, morning or evening, daily.
How often can you use Ferments / Probiotics?
- Daily.
Where do you apply Ferments / Probiotics?
- All over the face. Keep it away from your eyes and lips.
Does Ferments / Probiotics make skin more sensitive to the sun?
- No. Ferments / Probiotics is not flagged as increasing sun sensitivity.
What should you not use with Ferments / Probiotics?
- Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Ferments / Probiotics — check the label of anything not covered here.
Who should avoid Ferments / Probiotics?
- Go slowly with Fragile or Sensitive and Recent Facial or Laser.
Is there a cosmetic limit for Ferments / Probiotics?
- No. No cosmetic regulator in the United States, Canada, the European Union or Great Britain sets a maximum strength for it. That is a limit on the rules, not a signal to use more.
Related ingredients#
How we check this#
Everything on this page traces to the sources listed below — regulators' own publications and published studies. Where the evidence does not answer a question, it is left unanswered.
Some sources below are the official product information for prescription medicines — some contain this ingredient at higher strengths, others are cited for how they interact with it. We use them for their safety and handling detail only. A cosmetic product is not one of those medicines and is not intended to treat any condition.
Our review is AI-assisted and is not a named expert's opinion. Last reviewed August 4, 2026.
Think something here is out of date or wrong? Email us at wiki@skinintelligence.ai with your reasoning and where you read it. We read what people send, and we update the page when the sources support it.
Regulators and official bodies · 22
- S1Cosmetic Ingredient Review Expert Panel for Cosmetic Ingredient Safety. Safety Assessment of Yeast-Derived Ingredients as Used in Cosmetics. Final Report, December 2023. — Tier 1..
- S2Cosmetic Ingredient Review Expert Panel for Cosmetic Ingredient Safety. Safety Assessment of Lactobacillus Ferment Ingredients as Used in Cosmetics. Draft Final Report for Panel Review, September 2025 — the document is marked "Distributed for Comment Only — Do Not Cite or Quote" and is cited here as a draft, not as a settled CIR conclusion. — Tier 1 body, draft status..
- S3European Commission, CosIng — Cosmetic Ingredient Database. Entry: LACTOBACILLUS FERMENT. — Tier 1..
- S14Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products, Annex II (prohibited substances) and Annex III (restricted substances). — Tier 1. Searched for micro-organism, bacteri-, yeast, ferment, Lactobacillus, Saccharomyces, Bifido and Galactomyces: no entry.
- S15Assimilated Regulation (EC) No 1223/2009 as it forms part of the law of the United Kingdom, Annex II and Annex III. and /annex/III — Tier 1. Same search, same absence.
- S17National Rosacea Society. Survey Shows Skin Care Products, Ingredients May Aggravate Rosacea. Rosacea Review, Summer 1997. — Tier 1 (NRS)..
- S18National Rosacea Society. Skin Care and Cosmetics. — Tier 1 (NRS)..
- S21Health Canada. Cosmetic Ingredient Hotlist: Prohibited and Restricted Ingredients, and the Hotlist tables themselves. — Tier 1. Searched for micro-organism, probiotic, bacteri-, yeast, ferment, Lactobacillus, Saccharomyces, Bifido and Galactomyces: no entry.
- S22US Food and Drug Administration. Prohibited & Restricted Ingredients in Cosmetics. — Tier 1. Same search, no entry.
- S24Roaccutane 10 mg / 20 mg soft capsules (isotretinoin) — Summary of Product Characteristics, emc. — Tier 1..
- S25Treclin 1 %/0.025 % w/w Gel (clindamycin / tretinoin) — Summary of Product Characteristics, emc. — Tier 1..
- S26MotherToBaby. Cosmetics and Cosmetic Treatments in Pregnancy and Breastfeeding. — Tier 1. Contains no ferment- or probiotic-specific statement.
- S27Differin Gel (adapalene) — Summary of Product Characteristics, emc. — Tier 1..
- S28Tetralysal 300 mg Hard Capsules (lymecycline) — Summary of Product Characteristics, emc. — Tier 1. No cosmetic or topical statement.
- S29Deximune 25 mg soft capsules (ciclosporin) — Summary of Product Characteristics, emc. — Tier 1. Restricts live attenuated vaccines; silent on cosmetics.
- S30Methotrexate 2.5 mg Tablets BP — Summary of Product Characteristics, emc. — Tier 1. Contraindicates concomitant live vaccine; silent on cosmetics.
- S31Regulation (EC) No 1223/2009, Annex I Part A §3 (Microbiological quality), as assimilated in UK law. — Tier 1..
- S32MHRA. Product search: "lactobacillus ferment" — "There are no search results for lactobacillus ferment." — Tier 1. No licensed UK medicine, therefore no SmPC exists for this class.
- S33Commission Regulation (EU) No 655/2013 of 10 July 2013 laying down common criteria for the justification of claims used in relation to cosmetic products. CELEX 32013R0655. — Tier 1..
- S34Assimilated Commission Regulation (EU) No 655/2013 as it forms part of UK law. — Tier 1..
- S35US Food and Drug Administration. Microbiological Safety and Cosmetics. — Tier 1..
- S36Health Canada. Natural Health Products Ingredient Database — Probiotics monograph, 27 January 2023. — Tier 1..
Studies and references · 17
- S4Miyamoto K, Dissanayake B, Omotezako T, Takemura M, Tsuji G, Furue M. Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula. J Clin Med. 2021;10(11):2502. PMID 34198790. Tier 2; manufacturer (P&G) study; two cohorts, no placebo arm..
- S5Cui H, Feng C, Zhang T, Martínez-Ríos V, Martorell P, Tortajada M, Cheng S, Cheng S, Duan Z. Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study. Sci Rep. 2023;13(1):16879. PMID 37803101. Tier 2; manufacturer study; the authors state "the rigorous evidence may not be obtained from this study due to lacking the placebo group"..
- S6Guéniche A, Bastien P, Ovigne JM, Kermici M, Courchay G, Chevalier V, Breton L, Castiel-Higounenc I. Bifidobacterium longum lysate, a new ingredient for reactive skin. Exp Dermatol. 2010;19(8):e1-8. PMID 19624730. Tier 2; randomised, double-blind, vehicle-controlled, n = 66 — the strongest controlled trial in this class; L'Oréal-affiliated..
- S7Nakajima A, Sakae N, Yan X, Hakozaki T, Zhao W, Laughlin T, Furue M. Transcriptomic Analysis of Human Keratinocytes Treated with Galactomyces Ferment Filtrate, a Beneficial Cosmetic Ingredient. J Clin Med. 2022;11(16):4645. PMID 36012891. Tier 2; in vitro; P&G co-authorship..
- S8Snowball JM, Jarrold BB, DeAngelis Y, Li C, Rovito HA, Hare MC, Laughlin T, Evdokiou AL, Oblong JE. Integration of transcriptomics and spatial biology analyses reveals Galactomyces ferment filtrate promotes epidermal interconnectivity via induction of keratinocyte differentiation, proliferation and cellular bioenergetics. Int J Cosmet Sci. 2024;46(6):927-940. PMID 38924095. Tier 2; ex vivo human skin; all authors are employees of The Procter & Gamble Company..
- S9Wang R, Yan S, Ma X, Zhao J, Han Y, Pan Y, Zhao H. The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro. J Cosmet Dermatol. 2023;22(12):3427-3435. PMID 37218728. Tier 2; in vitro only..
- S10Miyamoto K, Inoue Y, Yan X, Yagi S, Suda S, Furue M. Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months. J Clin Med. 2023;12(3):1168. PMID 36769815. Tier 2; single-arm, uncontrolled, three whole SK-II products, n = 86, ethics approval by P&G Innovation Godo Kaisya..
- S11Anwar AI, Adriani A, Rimayani S, Anwar AA, Seweng A, Munirah R, Dewi WS, Kurniadi I. The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color. Skinmed. 2021;19(2):110-115. PMID 33938432. Tier 2; randomised placebo-controlled, FST IV–V, n = 51; three actives, no GFF-alone arm; low-impact journal..
- S12Study of Lactobacillus brevis DSM17250 extract ointment for leg xerosis (n = 30, placebo and untreated internal control, 28 days), as reported in [19]. Tier 2, reported at second hand — cited only for direction, never for a number that matters..
- S13Anwar AI, Wahab S, Widita W, Nurdin AR, Budhiani S, Seweng A. Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals. Dermatol Ther. 2019;32(6):e13146. PMID 31664751. Tier 2; three-arm RCT, n = 44, forearm application; 4 % GFF co-formulated with tranexamic acid, 2 % niacinamide and 4 % alpha arbutin..
- S16Tsuji G, Hashimoto-Hachiya A, Matsuda-Taniguchi T, Takai-Yumine A, Takemura M, Yan X, Furue M, Nakahara T. Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes. Front Immunol. 2022;13:745997. PMID 35663970. Tier 2; in vitro; P&G co-authorship..
- S19Theodorou IM, Kapoukranidou D, Theodorou M, Tsetis JK, Menni AE, Tzikos G, Bareka S, Shrewsbury A, Stavrou G, Kotzampassi K. Cosmeceuticals: A Review of Clinical Studies Claiming to Contain Specific, Well-Characterized Strains of Probiotics or Postbiotics. Nutrients. 2024;16(15):2526. PMID 39125405. Tier 2; critical review, and the source of the split-face postbiotic trial description (ClinicalTrials.gov NCT05048121, n = 50, double-blind, intra-individual) and of the L. brevis xerosis study at [12]..
- S20Abedin ZU, Shah A, Mazhar S, Khan SM, Aamir AB, Yousaf S, Fnu D, Mahato RK, Ansari A. Lactobacillus-Based Microbiome Therapy for Acne Vulgaris: A GRADE Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Cosmet Dermatol. 2026;25(3):e70792. PMID 41853869. Tier 2; 5 RCTs, n = 332; null result..
- S23Warp PV, Bilik SM, Ferrari LM, Keri JE. Prebiotics, Probiotics, and Postbiotics for Acne Vulgaris: A Systematic Review. Dermatol Ther (Heidelb). 2026;16(3):1531-1550. PMID 41703218. Tier 2; 33 studies, 2 112 patients; pools uncontrolled percentages and mixes oral with topical and live with inactivated..
- S37Miyamoto K, Munakata Y, Yan X, Tsuji G, Furue M. Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer. J Clin Med. 2022;11(8):2121. PMID 35456214. Tier 2; manufacturer study..
- S38Crabtree S, Jarrold BB, Kent O, Ehrman MC, Hawkins TJ, Korolchuk V, Braga CP, Snowball JM, Tamura M, Hakozaki T, Matsubara A, Oblong JE, Brown M. Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro. Int J Cosmet Sci. 2026;48(1):16-29. PMID 40708474. Tier 2; in vitro; P&G co-authorship; cited only to note that the mechanical finding is cell-level, not skin-level..
- S39Klimek-Szczykutowicz M, Błońska-Sikora EM, Kulik-Siarek K, Zhussupova A, Wrzosek M. Bioferments and Biosurfactants as New Products with Potential Use in the Cosmetic Industry. Appl Sci. 2024;14(9):3902. — Tier 2; narrative review, not PubMed-indexed; used only for the tight-junction and secondary-study descriptions, never for a primary number..



