Licorice Root Extract

A gentle plant extract that helps dark spots and uneven patches look lighter, while calming the look of redness at the same time.

On a label you may see
Licorice, Liquorice, Glabridin, Licochalcone and Glycyrrhiza

Last reviewed August 6, 2026 · 51 sources, 7 of them regulators or official bodies · how we check this

Best time
Morning or evening
How often
Daily
Strength
Gentle
Sun sensitivity
None

Where to apply

All over the face

Never in your eyes or on your lips.

What does Licorice Root Extract do?#

Licorice root extract contains naturally derived brightening compounds that help promote a more even, luminous-looking complexion. It gently addresses the appearance of dark spots while also supporting a calmer, less irritated-looking skin tone.

  • Helps promote a brighter, more even-looking complexion
  • Supports a calmer appearance, helping to reduce the look of redness and irritation
  • Gentle enough for daily use on all skin types, including sensitive skin
  • Contains multiple naturally derived compounds that support both brightening and calming benefits

How it works

Licorice root extract contains several naturally derived compounds, each contributing something different: some help even out the look of dark spots, while others help calm the appearance of redness and irritation. Its gentle, soothing nature makes it one of the most well-tolerated brightening ingredients available, suitable for sensitive skin and daily use.

How to use Licorice Root Extract#

  • Morning or evening, after cleansing and before moisturizer. Both suit it, and twice a day is fine.
  • Across the face, or just on the areas you want to even out.
  • Daily from the first day. There is no need to build up slowly, no settling-in period to push through, and no purge.
  • Expect it to work gradually. This is a several-weeks ingredient rather than a several-days one, so the useful thing is to keep going.
  • It is one of the gentlest brightening ingredients there is, which is why it suits sensitive skin and sits comfortably next to almost anything else in a routine.
  • Wear sunscreen daily. Sun exposure is what drives the marks you are working on — licorice root itself does not make skin more sun-sensitive.
  • If your skin is broken or actively irritated, let it settle before you start.

Discontinue use if unexpected discomfort occurs.

The form you will see it in

Licorice root brightening serum

Where it goes
Before moisturizer

Using Licorice Root Extract with other ingredients

Pairs well with Licorice Root Extract

Niacinamide

Works well together

Complementary brightening support — together they help promote a more even, radiant-looking complexion from two different angles.

Tranexamic acid

Works well together

Together they provide multi-level brightening support for a more uniform appearance, especially for stubborn dark spots.

Vitamin C

Works well together

Vitamin C in the morning and licorice root in the evening — the pair supports a brighter, more even-looking complexion better than licorice root on its own.

What not to use with Licorice Root Extract

Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Licorice Root Extract — check the label of anything not covered here.

Who should avoid Licorice Root Extract?#

Six situations change whether Licorice Root Extract suits your skin right now. Each one is either a reason to skip it, a reason to go slowly, or nothing to watch for.

Maternity & Nursing
Go slowly
Fragile or Sensitive
Go slowly
Recent Facial or Laser
No caution
Prone to Redness
No caution
Dry or Itchy Patches
No caution
Recent Shave or Wax
No caution

Maternity & NursingIf you are pregnant or nursing, you may prefer to check with your healthcare provider before use.

Fragile or SensitiveUse it less often — or stop — if it feels uncomfortable, and keep it off skin that’s broken, cut or sunburned.

Cosmetic strength limits for Licorice Root Extract where you live#

RegionMaximum strength
United StatesNo explicit cap
CanadaNo explicit cap
European UnionNo explicit cap
Great BritainNo explicit cap

No cosmetic regulator in these four markets sets a maximum strength for licorice root extract. That is a limit on the rules, not a signal to use more: how much goes into a product is the formulator's decision.

Products with Licorice Root Extract#

We may earn a small commission when you buy through these links.

Common questions about Licorice Root Extract#

When should you apply Licorice Root Extract?

Morning or evening, after cleansing and before moisturizer. Both suit it, and twice a day is fine.

How often can you use Licorice Root Extract?

Daily.

Where do you apply Licorice Root Extract?

All over the face. Keep it away from your eyes and lips.

Does Licorice Root Extract make skin more sensitive to the sun?

No. Licorice Root Extract is not flagged as increasing sun sensitivity.

What should you not use with Licorice Root Extract?

Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Licorice Root Extract — check the label of anything not covered here.

Who should avoid Licorice Root Extract?

Go slowly with Maternity & Nursing and Fragile or Sensitive.

Is there a cosmetic limit for Licorice Root Extract?

No. No cosmetic regulator in the United States, Canada, the European Union or Great Britain sets a maximum strength for it. That is a limit on the rules, not a signal to use more.

How we check this#

Everything on this page traces to the sources listed below — regulators' own publications and published studies. Where the evidence does not answer a question, it is left unanswered.

Our review is AI-assisted and is not a named expert's opinion. Last reviewed August 6, 2026.

Think something here is out of date or wrong? Email us at wiki@skinintelligence.ai with your reasoning and where you read it. We read what people send, and we update the page when the sources support it.

Studies and references · 44

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  2. S9Weber TM, Ceilley RI, Buerger A, Kolbe L, Trookman NS, Rizer RL, Schoelermann A. Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A. J Cosmet Dermatol. 2006;5(3):227–32. PMID 17177744.
  3. S10Schoelermann AM, Weber TM, Arrowitz C, Rizer RL, Qian K, Babcock M. Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I. JEADV. 2016;30(Suppl 1):21–7. PMID 26805419.
  4. S11Sulzberger M, Worthmann AC, Holtzmann U, Buck B, Jung KA, Schoelermann AM, Rippke F, Stäb F, Wenck H, Neufang G, Grönniger E. Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A. JEADV. 2016;30(Suppl 1):9–17. PMID 26805417.
  5. S12Saric S, Clark AK, Sivamani RK, Lio PA, Lev-Tov HA. The Role of Polyphenols in Rosacea Treatment: A Systematic Review. J Altern Complement Med. 2017;23(12):920–9. PMID 28650692.
  6. S13Udompataikul M, Srisatwaja W. Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: a pilot study. JEADV. 2011;25(6):660–5. PMID 20840345.
  7. S14Wananukul S, Chatproedprai S, Chunharas A, Limpongsanuruk W, Singalavanija S, Nitiyarom R, Wisuthsarewong W. Randomized, double-blind, split-side, comparison study of moisturizer containing licochalcone A and 1% hydrocortisone in the treatment of childhood atopic dermatitis. J Med Assoc Thai. 2013;96(9):1135–42. PMID 24163988.
  8. S15Wananukul S, Chatproedprai S, Charutragulchai W. Randomized, double-blind, split-side comparison study of moisturizer containing licochalcone vs. 1% hydrocortisone in the treatment of infantile seborrhoeic dermatitis. JEADV. 2012;26(7):894–7. PMID 21790793.
  9. S16Saeedi M, Morteza-Semnani K, Ghoreishi MR. The treatment of atopic dermatitis with licorice gel. J Dermatolog Treat. 2003;14(3):153–7. PMID 14522625.
  10. S17Amer M, Metwalli M. Topical liquiritin improves melasma. Int J Dermatol. 2000;39(4):299–301. PMID 10809983.
  11. S18Cerulli A, Masullo M, Montoro P, Piacente S. Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients. Cosmetics. 2022;9(1):7. DOI 10.3390/cosmetics9010007.
  12. S19Hoffmann J, Gendrisch F, Schempp CM, Wölfle U. New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders. Biomedicines. 2020;8(2):27. DOI 10.3390/biomedicines8020027.
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  15. S22Yokota T, Nishio H, Kubota Y, Mizoguchi M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res. 1998;11(6):355–61. PMID 9870547.
  16. S23Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003;51(5):1201–7. PMID 12590456.
  17. S24Uto T, Ohta T, Yamashita A, Fujii S, Shoyama Y. Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways. Medicines (Basel). 2019;6(2):68. PMID 31234488.
  18. S25Costa A, Moisés TA, Cordero T, Alves CR, Marmirori J. Association of emblica, licorice and belides as an alternative to hydroquinone in the clinical treatment of melasma. An Bras Dermatol. 2010;85(5):613–20. PMID 21152784.
  19. S26Draelos ZD, Diaz I. The clinical benefit of a multimodal topical approach to treating skin dyspigmentation. J Cosmet Dermatol. 2023;22(6):1799–804. PMID 37102219.
  20. S27Zhang T, Wang Y, Xu Y, Liu Y, Zhuang B, Zhang X, Liao C, Liu W, Ma Y. Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio. Skin Res Technol. 2026. DOI 10.1111/srt.70334.
  21. S28Xing M, Wang X, Zhao L, Zhou Z, Liu H, Wang B, Cheng A, Zhang S, Gao Y. Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract. Int J Pharm. 2021;600:120406. PMID 33711468.
  22. S29Kim BH, Lee YS, Kang KS. The mechanism of retinol-induced irritation and its application to anti-irritant development. Toxicol Lett. 2003;146(1):65–73. PMID 14615068.
  23. S30O'Connell RL, White IR, White JM, McFadden JP. Liquorice extract in a cosmetic product causing contact allergy. Contact Dermatitis. 2008;59(1):52. PMID 18598306.
  24. S31Kimyon RS, Liou YL, Schlarbaum JP, Warshaw EM. Allergic Contact Dermatitis to Licorice Root Extract. Dermatitis. 2019;30(3). PMID 31045935.
  25. S32Gatica-Ortega ME, Pastor-Nieto MA. Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti-acne cosmetic product. Contact Dermatitis. 2021;85(4). PMID 33913165.
  26. S33Sánchez-García V, Taboada-Paz L, Hernández-Quiles R, Betlloch-Mas I, Silvestre JF. Allergic contact dermatitis from glycyrrhetinic acid contained in a cream for palpebral eczema. Contact Dermatitis. 2023;88(4). PMID 36573308.
  27. S34NCCIH. Licorice Root: Usefulness and Safety. Last updated April 2025.
  28. S35Xie Y, Huang J, Liu J, Zhang Q. Efficacy of diammonium glycyrrhizinate in the treatment of rosacea with papules and pustules: A randomized, double-blind, placebo-controlled study. Dermatol Ther. 2022;35(12):e15905. PMID 36200523.
  29. S36Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient… Regul Toxicol Pharmacol. 2006;46(3):167–92. PMID 16884839.
  30. S37Räikkönen K, Martikainen S, Pesonen AK, Lahti J, Heinonen K, Pyhälä R, Lahti M, Tuovinen S, et al. Maternal Licorice Consumption During Pregnancy and Pubertal, Cognitive, and Psychiatric Outcomes in Children. Am J Epidemiol. 2017;185(5). PMID 28158597.
  31. S38Kantikosum K, Chongpison Y, Chottawornsak N, Asawanonda P. The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study. Clin Cosmet Investig Dermatol. 2019;12:151–61. PMID 30858720.
  32. S39Puaratanaarunkon T, Asawanonda P. A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser. Clin Cosmet Investig Dermatol. 2022;15:331–7. PMID 35250287.
  33. S40Boonchai W, Varothai S, Winayanuwattikun W, Phaitoonvatanakij S, Chaweekulrat P, Kasemsarn P. Randomized investigator-blinded comparative study of moisturizer containing 4-t-butylcyclohexanol and licochalcone A versus 0.02% triamcinolone acetonide cream in facial dermatitis. J Cosmet Dermatol. 2018;17(6). PMID 29411520.
  34. S41Kowalska A, Kalinowska-Lis U. 18β-Glycyrrhetinic acid: its core biological properties and dermatological applications. Int J Cosmet Sci. 2019;41(4):325–31. PMID 31166601.
  35. S42Ao M, Shi Y, Cui Y, Guo W, Wang J, Yu L. Factors influencing glabridin stability. Nat Prod Commun. 2010;5(12):1907–12. PMID 21299118.
  36. S43Hollinger JC, Angra K, Halder RM. Are Natural Ingredients Effective in the Management of Hyperpigmentation? A Systematic Review. J Clin Aesthet Dermatol. 2018;11(2):28–37. PMID 29552273.
  37. S44Alexis AF, Blackcloud P. Natural ingredients for darker skin types: growing options for hyperpigmentation. J Drugs Dermatol. 2013;12(9 Suppl):s123–7. PMID 24002160.
  38. S45Cantelli M, Ferrillo M, Donnarumma M, Emanuele E, Fabbrocini G. A new proprietary gel containing glabridin, andrographolide, and apolactoferrin improves the appearance of epidermal melasma in adult women: A 6-month pilot, uncontrolled open-label study. J Cosmet Dermatol. 2020;19(6):1395–8. PMID 31541594.
  39. S46Chen J, Yu X, Huang Y. Inhibitory mechanisms of glabridin on tyrosinase. Spectrochim Acta A Mol Biomol Spectrosc. 2016;168:111–7. PMID 27288962.
  40. S47Ivosevic-Zaper J, Hofmann M, Kakadjanova A, Valesky E, Meissner M, Bereiter-Hahn J, Kaufmann R, Bernd A, Kippenberger S. Topically applied glycyrrhizic acid causes hair removal in rats. Pharm Biol. 2014;52(10):1362–5. PMID 24785361.
  41. S48Cantelli M, Ferrillo M, Granger C, Fabbrocini G. An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen… J Cosmet Dermatol. 2022;21(4). PMID 34087055.
  42. S49Liu D, Jiang X, Yang F, Zhou J, Li Y, Yang H. Therapeutic potential of Licochalcone A in dermatological diseases: from basic to clinical research. Front Pharmacol. 2025;16. PMID 41181588.
  43. S50Murphy MJ, Dow AA. Natural Cosmeceutical Ingredients for the Management of Hyperpigmentation in Hispanic and Latino Women. J Clin Aesthet Dermatol. 2021;14(8). PMID 34840659.
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