Where do you apply PDRN?

All over the face. Keep it away from your eyes and lips.

Does PDRN make skin more sensitive to the sun?

No. PDRN is not flagged as increasing sun sensitivity.

Is there a cosmetic limit for PDRN?

No. No cosmetic regulator in the United States, Canada, the European Union or Great Britain sets a maximum strength for it. That is a limit on the rules, not a signal to use more.

PDRN — What It Does & How to Use It

What does PDRN do?#

A leave-on serum with PDRN, a DNA fragment from salmon or trout, used to help skin look firmer and smoother — most of all around the eyes.

Benefits

Helps soften the look of fine lines, with the clearest results around the eyes
Helps skin look firmer and springier over a few weeks of daily use
Gentle enough for morning and night, including on the thin skin near the eyes
Sits quietly alongside the rest of a routine — the app never asks you to time it around anything

How it works

PDRN is a fragment of DNA taken from salmon or trout milt and purified. Unlike a moisturiser, which changes how skin looks and feels on the surface straight away, it settles in slowly and its effect builds. That is why it is counted in weeks rather than days, and why it shows up as a firmer, smoother look rather than an instant change in feel.

How to use PDRN#

Before you start
It is purified from the milt of salmon or trout, so it is not vegan. Plant-sourced versions exist and are a different material, studied separately.
Where it goes
A serum goes on after cleansing and before your moisturiser. It suits morning and night alike, and there is no reason to keep it to one or the other.
Where to apply
All over the face, and right up to the orbital bone — the study behind it used an eye cream. Keep it out of the eye itself, as with any leave-on.
How to apply
A thin layer on clean skin. It is absorbed slowly by nature, so give it a moment to settle before the next step.
Alongside others
It layers easily with the rest of a routine. If a retinoid or an acid already makes skin feel tight, put this on afterwards, onto skin that has settled.
What to expect
A quiet start. There is no break-in phase and no flaking — the studies measured steady change from about two weeks, with four weeks the point they stopped counting.
What to look for
An ingredient list names it but never gives its molecule size, and size is what decides whether a product does much. Seeing Sodium DNA on a label tells you the ingredient is there, not how it will behave.
If it doesn't suit
It is not usually the thing that stings or flakes, but skin is individual. If something in your routine does — including this one — pause it, let skin settle, and reintroduce it on its own.

Discontinue use if unexpected discomfort occurs.

The form you will see it in

PDRN firming serum

Where it goes: Before moisturizer

Using PDRN with other ingredients

What not to use with PDRN

Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from PDRN — check the label of anything not covered here.

Who should avoid PDRN?#

Six situations change whether PDRN suits your skin right now. Each one is either a reason to skip it, a reason to go slowly, or nothing to watch for.

Maternity & Nursing: Go slowly
Fragile or Sensitive: No caution
Recent Facial or Laser: No caution
Prone to Redness: No caution
Dry or Itchy Patches: No caution
Recent Shave or Wax: No caution

Maternity & Nursing — If you are pregnant or nursing, you may prefer to check with your healthcare provider before use.

Cosmetic strength limits for PDRN where you live#

Region	Most a cosmetic may contain
United States	No explicit cap
The FDA restricts a short list of ingredients and sets no general strength ceiling on the rest. A figure marked "guidance, not law" is the Cosmetic Ingredient Review panel's recommendation. 21 CFR part 700, subpart B — Requirements for Specific Cosmetic Products (FDA)
Canada	No explicit cap
One list does the work — Health Canada's Hotlist of prohibited and restricted cosmetic ingredients. Health Canada — Cosmetic Ingredient Hotlist
European Union	No explicit cap
The Cosmetics Regulation's annexes, consolidated to 1 May 2026. A figure marked "guidance, not law" comes from the EU's cosmetic safety committee rather than from the annexes. Regulation (EC) No 1223/2009, Annexes II–VI
Great Britain	No explicit cap
Great Britain kept the annexes as its own law and updates them only when it chooses; Northern Ireland follows the live EU Regulation, which is why some rows read differently for each. Regulation (EC) No 1223/2009 as it applies in Great Britain · Regulation (EC) No 1223/2009, Annexes II–VI
India	No explicit cap
India writes its own standard, aligned to the European rules as they stood in 2012. Mandatory since 9 February 2026. IS 4707 (Part 2):2025 — restricted and prohibited cosmetic ingredients · IS 4707 (Part 3):2025 — preservatives · Cosmetics Rules, 2020, Ninth Schedule
Brazil	No explicit cap
ANVISA rewrote its restricted list in June 2026, and a companion act amended the prohibited list at the same time. RDC 1.029/2026 — restricted ingredients · RDC 529/2021 — prohibited ingredients, as amended by RDC 1.030/2026 · RDC 528/2021 — preservatives
Japan	No explicit cap
Japan's cosmetics standard keeps drug ingredients out of cosmetics, so most of its figures sit in the ministry's list of the ones a cosmetic may still contain. Cosmetics Standards (化粧品基準), Ministry of Health, Labour and Welfare · Cosmetics Standards — the ministry's own English translation · Drug ingredients permitted in cosmetics — 2007 notification
South Korea	No explicit cap
One MFDS regulation carries both the prohibited list and the restricted list, in force 18 March 2026. Sunscreens and a few other categories are cleared product by product instead. Regulation on Safety Standards for Cosmetics (MFDS Notification 2026-19) · Regulation on the Review of Functional Cosmetics (MFDS Notification 2025-88)
Kenya	No explicit cap
Kenya's standard applies the EU annexes as they stand rather than copying them, so its ingredient limits are the EU's — including the 2024 additions. A figure marked "guidance, not law" sits outside the annexes and does not carry over. KS EAS 377-1, -2 and -3:2022 — cosmetics safety requirements, published by KEBS · Regulation (EC) No 1223/2009, Annexes II–VI
Namibia	No explicit cap
Namibia sets no ingredient limits at all. Its cosmetic rule is a single line requiring a product to be free of any harmful ingredient. Foodstuffs, Cosmetics and Disinfectants Ordinance 18 of 1979, and the regulations under it
Ukraine	No explicit cap
Ukraine's own transposition of the EU annexes, as they stood before the 2024 additions, fully in force since 3 August 2026. A further revision is due on 1 February 2027. Technical Regulation on cosmetic products — Cabinet Resolution No. 65 of 20 January 2021
Georgia	No explicit cap
Georgia has no cosmetics rulebook — its register of technical regulations carries no cosmetics entry — so only the general product-safety duty applies. Register of technical regulations — no cosmetics entry
Australia	No explicit cap
Australia writes no cosmetic ingredient list. A figure here is the point at which a substance becomes a medicine or a scheduled substance carrying Caution labelling, so its numbers sit well above other markets'. Poisons Standard — June 2026 · Therapeutic Goods (Excluded Goods) Determination 2018
United Arab Emirates	No explicit cap
The Gulf standard points at the EU annexes as amended, so its ingredient limits are the EU's. A figure marked "guidance, not law" sits outside the annexes and does not carry over. GSO 1943:2024 — Cosmetic products: safety requirements (Gulf technical regulation) · Regulation (EC) No 1223/2009, Annexes II–VI
Kuwait	No explicit cap
The Gulf standard points at the EU annexes as amended, so its ingredient limits are the EU's. A figure marked "guidance, not law" sits outside the annexes and does not carry over. GSO 1943:2024 — Cosmetic products: safety requirements (Gulf technical regulation) · Regulation (EC) No 1223/2009, Annexes II–VI
Hong Kong	No explicit cap
Hong Kong writes no cosmetics rulebook. Its Poisons List (Cap. 138A, Schedule 10) decides which substances may be sold only as medicines, and general safety is judged case by case against whichever overseas standard the enforcer considers reasonable. Pharmacy and Poisons Regulations (Cap. 138A), Schedule 10 — the poisons list · Pharmacy and Poisons Board — Guidance Notes on classifying pharmaceutical products, April 2026
Singapore	No explicit cap
Singapore writes the ASEAN annexes into its own schedule, and its regulator tells companies to check the current ASEAN release as well — which is why a figure here can read "guidance, not law". Health Products (Cosmetic Products — ASEAN Cosmetic Directive) Regulations 2007, Third Schedule · ASEAN Cosmetic Directive annexes — release 2026-1, 22 June 2026
Brunei	No explicit cap
Brunei carries the 2007 ASEAN annexes in its own schedule and has not updated them since, so it reads differently from Singapore on several ingredients. Medicines (Cosmetic Products) Regulations (Cap. 285 Rg 1), Schedule 1 — revised edition 2024
Jordan	No explicit cap
Jordan's cosmetic rules defer to "the approved references" and name none of them, so there is no Jordanian figure to read. The only number in the instrument governs the ingredient list on the pack. JFDA instructions on cosmetics and pharmaceutical cosmetics, 2026
Trinidad & Tobago	No explicit cap
Trinidad and Tobago has had the power to set cosmetic standards since 1960 and has never used it. The regulations made under the Act cover food and drugs, with no cosmetics part; what binds is the Act's general rule against selling a cosmetic that may injure the user. Food and Drugs Act, Chap. 30:01 · Food and Drugs Regulations

No cosmetic regulator in the 20 markets above sets a maximum strength for pdrn. That is the state of the rules, not a signal to use more: how much goes into a product is the formulator's decision.

Open a market to see the rulebook its figure comes from. Those notes describe each market's own rules as we read them, current to August 24, 2026; the linked documents are the authority, and nothing here is legal advice.

Common questions about PDRN#

When should you apply PDRN?: Morning or evening.
How often can you use PDRN?: Daily.
Where do you apply PDRN?: All over the face. Keep it away from your eyes and lips.
Does PDRN make skin more sensitive to the sun?: No. PDRN is not flagged as increasing sun sensitivity.
What should you not use with PDRN?: Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from PDRN — check the label of anything not covered here.
Who should avoid PDRN?: Go slowly with Maternity & Nursing.
Is there a cosmetic limit for PDRN?: No. No cosmetic regulator in the United States, Canada, the European Union or Great Britain sets a maximum strength for it. That is a limit on the rules, not a signal to use more.

Peptides Copper Peptides Retinol Peptides (Eye Area)Hyaluronic Acid

How we check this#

Everything on this page traces to the sources listed below — regulators' own publications and published studies. Where the evidence does not answer a question, it is left unanswered.

Some sources below are medical studies. This ingredient has been studied in conditions a doctor treats, and the record cited here includes findings that did not favour it. We use those studies for their safety and handling detail only. A cosmetic product is not a medicine and is not intended to treat, cure or prevent any condition.

Some sources below are the official product information for prescription medicines — some contain this ingredient at higher strengths, others are cited for how they interact with it. We use them for their safety and handling detail only. A cosmetic product is not one of those medicines and is not intended to treat any condition.

Our review is AI-assisted and is not a named expert's opinion. Last reviewed September 1, 2026.

Think something here is out of date or wrong? Email us at wiki@skinintelligence.ai with your reasoning and where you read it. We read what people send, and we update the page when the sources support it.

Regulators and official bodies · 11

Studies and references · 32