Resveratrol

A plant antioxidant from grapes, berries and Japanese knotweed that helps uneven-looking skin tone look more even over time.

On a label you may see
Trans-resveratrol

Last reviewed September 23, 2026 · 51 sources, 14 of them regulators or official bodies · how we check this

Best time
Morning or evening
How often
Daily
Strength
Gentle
Sun sensitivity
None

Where to apply

All over the face

Never in your eyes or on your lips.

What does Resveratrol do?#

A plant-derived antioxidant that helps uneven-looking skin tone look more even over time, while adding antioxidant support against everyday environmental stress.

Benefits

  • Helps uneven-looking skin tone look more even over time
  • Provides antioxidant support against everyday environmental stress
  • Gentle enough for morning and night, every day, with no easing-in period

How it works

Resveratrol is an antioxidant plants make to protect themselves — grape skins, berries and the root of Japanese knotweed are rich in it, and cosmetic resveratrol is purified from those or made to match. As an antioxidant it neutralizes the unstable molecules everyday environmental stress creates at the skin's surface, and in a placebo-controlled study of women over 40, a resveratrol cream used twice a day helped skin tone look more even over eight weeks. Japanese knotweed extract, grape extracts and resveratrol's chemical cousins appear on labels under their own names and are different ingredients.

How to use Resveratrol#

  • Before you start

    Patch test a small area before first use. Allergy to resveratrol has been reported from cosmetic creams.

  • Best time

    Morning or evening. The studies used it both ways, often twice a day.

  • How often

    Every day, from the first day, with no need to build up.

  • Where it goes

    After cleansing, before moisturizer.

  • Where to apply

    A thin layer across the whole face. Keep it out of the eyes themselves, as with any leave-on.

  • Sun

    Wear sunscreen daily. Resveratrol is not one we flag for extra sun care - and sun protection is its own separate step whatever else your routine contains.

  • Alongside others

    It is not an exfoliant, so it adds no extra exfoliation alongside acids or retinol.

  • What to expect

    Nothing much to feel - in a placebo-controlled study it was no more irritating than the plain cream. Any change in tone is gradual; that study ran for eight weeks. Cheeks can look a little shinier with regular use, and a lighter moisturizer over it helps if shine bothers you.

  • What to look for

    Japanese knotweed (Polygonum cuspidatum) extract, grape extracts and resveratrol's chemical cousins are different ingredients with their own names on a label. Some products put resveratrol in their name without it on the ingredient list, so check the list.

  • If it doesn't suit

    If an itchy, red rash appears, stop using it and don't restart.

  • Storing it

    Keep it closed, cool and out of light - resveratrol breaks down in light and heat.

Discontinue use if unexpected discomfort occurs.

The form you will see it in

Resveratrol serum

Where it goes
Before sunscreen

Using Resveratrol with other ingredients

What not to use with Resveratrol

Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Resveratrol — check the label of anything not covered here.

Who should avoid Resveratrol?#

Six situations change whether Resveratrol suits your skin right now. Each one is either a reason to skip it, a reason to go slowly, or nothing to watch for.

Fragile or Sensitive
Go slowly
Maternity & Nursing
No caution
Recent Facial or Laser
No caution
Prone to Redness
No caution
Dry or Itchy Patches
No caution
Recent Shave or Wax
No caution

Fragile or Sensitive — Use it less often — or stop — if it feels uncomfortable, and keep it off skin that’s broken, cut or sunburned.

Cosmetic strength limits for Resveratrol where you live#

RegionMost a cosmetic may contain

No cosmetic regulator in the 20 markets above sets a maximum strength for resveratrol. That is the state of the rules, not a signal to use more: how much goes into a product is the formulator's decision.

Open a market to see the rulebook its figure comes from. Those notes describe each market's own rules as we read them, current to August 24, 2026; the linked documents are the authority, and nothing here is legal advice.

Sample products with Resveratrol#

A few well-known products, not a full list — product names are each brand's own. We don't sell them — the shop prices them in US dollars and ships from Hong Kong, so delivery and duties come on top. It may not ship everywhere.

We may earn a small commission when you buy through these links.

Already have one? Check how it fits your skin with Pick.

Common questions about Resveratrol#

What is Resveratrol?

A plant antioxidant from grapes, berries and Japanese knotweed that helps uneven-looking skin tone look more even over time.

What else is Resveratrol called?

On a label you may see Trans-resveratrol.

When should you apply Resveratrol?

Morning or evening. Morning or evening. The studies used it both ways, often twice a day.

How often can you use Resveratrol?

Daily.

Where do you apply Resveratrol?

All over the face. Keep it away from your eyes and lips.

Can you use Resveratrol around the eyes?

Yes. Resveratrol goes all over the face, the skin around the eyes included — keep it out of your eyes and off your lips.

Does Resveratrol make skin more sensitive to the sun?

No. Resveratrol is not flagged as increasing sun sensitivity.

What should you not use with Resveratrol?

Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Resveratrol — check the label of anything not covered here.

Who should avoid Resveratrol?

Go slowly with Fragile or Sensitive.

Is there a cosmetic limit for Resveratrol?

No. No cosmetic regulator in the United States, Canada, the European Union or Great Britain sets a maximum strength for it. That is a limit on the rules, not a signal to use more.

How we check this#

Everything on this page traces to the sources listed below — regulators' own publications and published studies. Where the evidence does not answer a question, it is left unanswered.

Some sources below are medical studies. This ingredient has been studied in conditions a doctor treats, and the record cited here includes findings that did not favor it. We use those studies for their safety and handling detail only. A cosmetic product is not a medicine and is not intended to treat, cure or prevent any condition.

Some sources below are the official product information for prescription medicines, cited for how they interact with this ingredient. We use them for their safety and handling detail only. A cosmetic product is not one of those medicines and is not intended to treat any condition.

Our review is AI-assisted and is not a named expert's opinion. Last reviewed September 23, 2026.

Think something here is out of date or wrong? Email us at wiki@skinintelligence.ai with your reasoning and where you read it. We read what people send, and we update the page when the sources support it.

Studies and references · 37

  1. S1Rao A, Briskey D, Roche G, Tremblay A, Da Silva Pinto M, Tompkins TA. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial. Front Aging 2025. PMID 41488277.
  2. S2Fabbrocini G, Staibano S, De Rosa G, Battimiello V, Fardella N, Ilardi G, La Rotonda MI, Longobardi A, Mazzella M, Siano M, Pastore F, De Vita V, Vecchione ML, Ayala F. Resveratrol-containing gel for the treatment of acne vulgaris. Am J Clin Dermatol 2011. PMID 21348544.
  3. S3Farris P, Yatskayer M, Chen N, Krol Y, Oresajo C. Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin E. J Drugs Dermatol 2014. PMID 25607790.
  4. S4Ferzli G, Patel M, Phrsai N, Brody N. Reduction of facial redness with resveratrol added to topical product containing green tea polyphenols and caffeine. J Drugs Dermatol 2013. PMID 23884488.
  5. S5Igielska-Kalwat J, Firlej M, Lewandowska A, Biedziak B. In vivo studies of resveratrol contained in cosmetic emulsions. Acta Biochim Pol 2019. PMID 31518087.
  6. S6Wu Y, Jia LL, Zheng YN, Xu XG, Luo YJ, Wang B, Chen JZ, Gao XH, Chen HD, Matsui M, Li YH. Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation. J Eur Acad Dermatol Venereol 2013. PMID 22221158.
  7. S7Ryu JH, Seok JK, An SM, Baek JH, Koh JS, Boo YC. A study of the human skin-whitening effects of resveratryl triacetate. Arch Dermatol Res 2015. PMID 25750159.
  8. S8Boo YC. Human skin lightening efficacy of resveratrol and its analogs: from in vitro studies to cosmetic applications. Antioxidants (Basel) 2019. PMID 31443469.
  9. S9Degraeuwe A, Jacobs MC, Herman A. Allergic contact dermatitis caused by resveratrol in a cosmetic cream. Contact Dermatitis 2020. PMID 32060919 (author preprint).
  10. S10Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022. PMID 35462423.
  11. S11Gallo R, Viglizzo G, Vecchio F, Parodi A. Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol. Contact Dermatitis 2003. PMID 12755747.
  12. S12Gallo R, Pastorino C, Gasparini G, Ciccarese G, Parodi A. Scutellaria baicalensis extract: a novel botanical allergen in cosmetic products? Contact Dermatitis 2016. PMID 27870097.
  13. S13Zupančič Š, Lavrič Z, Kristl J. Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature. Eur J Pharm Biopharm 2015. PMID 25864442.
  14. S14Robinson K, Mock C, Liang D. Pre-formulation studies of resveratrol. Drug Dev Ind Pharm 2015. PMID 25224342.
  15. S15Juškaitė V, Ramanauskienė K, Briedis V. Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress. 2017. PMID 28590913.
  16. S16Freitas JV, Lopes NP, Gaspar LR. Photostability evaluation of five UV-filters, trans-resveratrol and beta-carotene in sunscreens. Eur J Pharm Sci 2015. PMID 26159738.
  17. S17Jensen JS, Wertz CF, O'Neill VA. Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (piceid). J Agric Food Chem 2010. PMID 20055412.
  18. S21Shi Y, Shen C, Zhang W. Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO₂ laser. J Eur Acad Dermatol Venereol 2024. PMID 38828801.
  19. S22Bjerring P, Draelos ZD, Fabi SG, et al. International expert consensus on integrated skincare active ingredients for pretreatment and posttreatment use with medical aesthetic procedures. J Cosmet Dermatol 2026. PMID 42087526 (text and Figure 1).
  20. S23Barbarino SC, Bucay VW, Cohen JL, Gold MH. Integrative skincare trial of intense pulsed light followed by the phyto-corrective mask, phyto-corrective gel, and resveratrol BE … in patients with rosacea. J Cosmet Dermatol 2022. PMID 35765796.
  21. S33Pastore S, Lulli D, Maurelli R, Dellambra E, De Luca C, Korkina LG. Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes. 2013. PMID 23527233.
  22. S34Park J, Park JH, Suh HJ, Lee IC, Koh J, Boo YC. Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis. Arch Dermatol Res 2014. PMID 24414332.
  23. S35Jo DJ, Seok JK, Kim SY, Park W, Baek JH, Kim YM, Boo YC. Human skin-depigmenting effects of resveratryl triglycolate. Int J Cosmet Sci 2018. PMID 29663438.
  24. S36Zhang Y, Huang J, Jia J, Jiang J, Ma X, Zhao L, Jing Y. Advances in understanding the functions and regulatory factors of secondary metabolites in Reynoutria japonica. Plant Signal Behav 2025. PMID 41046325.
  25. S37Cornacchione S, Sadick NS, Neveu M, et al. In vivo skin antioxidant effect of a new combination based on a specific Vitis vinifera shoot extract and a biotechnological extract. J Drugs Dermatol 2007. PMID 17691204.
  26. S38Sharif A, Akhtar N, Khan MS, Menaa A, Menaa B, Khan BA, Menaa F. Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract. Int J Cosmet Sci 2015. PMID 25402429.
  27. S39Cui Q, Wang H. Resveratrol in dermatological therapy: a critical review. Clin Cosmet Investig Dermatol 2025. PMID 40948611.
  28. S40Marko M, Pawliczak R. Resveratrol and its derivatives in inflammatory skin disorders — atopic dermatitis and psoriasis: a review. Antioxidants (Basel) 2023. PMID 38001807.
  29. S41Saitoh Y, Umezaki T, Yonekura N, Nakawa A. Resveratrol potentiates intracellular ascorbic acid enrichment … in HaCaT cells. Mol Cell Biochem 2020. PMID 32080778.
  30. S42Yanez M, Jhanji M, Murphy K, Gower RM, Sajish M, Jabbarzadeh E. Nicotinamide augments the anti-inflammatory properties of resveratrol through PARP1 activation. Sci Rep 2019. PMID 31308445.
  31. S43Turcov D, Barna AS, Blaga AC, Ibanescu C, Danu M, Trifan A, Zbranca A, Suteu D. Dermatocosmetic emulsions based on resveratrol, ferulic acid and saffron extract. Pharmaceutics 2022. PMID 36365195.
  32. S44Clinical evaluation of an antioxidant cream containing resveratrol, ferulic acid, and vitoptin on photodamaged skin. J Am Acad Dermatol meeting abstract (authors not captured in the record).
  33. S45Na JI, Shin JW, Choi HR, Kwon SH, Park KC. Resveratrol as a multifunctional topical hypopigmenting agent. Int J Mol Sci 2019. PMID 30813264.
  34. S46Mittra I. Exploiting the damaging effects of ROS for therapeutic use by deactivating cell-free chromatin: the alchemy of resveratrol and copper. Front Pharmacol 2024. PMID 38455966.
  35. S47Hecker A, Schellnegger M, Hofmann E, Luze H, Nischwitz SP, Kamolz LP, Kotzbeck P. The impact of resveratrol on skin wound healing, scarring, and aging. Int Wound J 2022. PMID 33949795 (clinical-study table used to cross-check [3][5]).
  36. S48Lin MH, Hung CF, Sung HC, Yang SC, Yu HP, Fang JY. The bioactivities of resveratrol and its naturally occurring derivatives on skin. J Food Drug Anal 2021. PMID 35696226.
  37. S50Zatloukalova M, Hanyk J, Papouskova B, Kabelac M, Vostalova J, Vacek J. Tapinarof and its structure-activity relationship for redox chemistry and phototoxicity on human skin keratinocytes. Free Radic Biol Med 2024. PMID 39067626 (resveratrol and pterostilbene as comparators).

Skin Intelligence is a cosmetic skincare tool, not a medical device, and does not diagnose, treat, cure, or prevent any condition. Always follow the directions on the product you are using — where they differ from anything on this page, the label takes precedence. If you have a skin concern, please see a healthcare professional.

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