What does Ceramides do?#
Ceramides are naturally present in your skin and are used in skincare to help skin look and feel more hydrated, comfortable, and resilient. Topical ceramides complement the skin's own lipids for a healthier-looking appearance.
Benefits
- Helps support a healthier-looking skin surface for improved moisture retention
- Supports a stronger-looking skin surface that resists dryness and environmental stress
- Well tolerated by most skin types, including dry and sensitive skin
How it works
Ceramides are natural lipids found abundantly in your skin. When applied topically, they complement the skin's own lipid composition, helping skin look and feel more hydrated and comfortable. Formulations that include ceramides alongside cholesterol and fatty acids mirror the skin's natural makeup, supporting a smoother, more resilient-looking skin surface over time.
How to use Ceramides#
How often
There is nothing to ease into — a full amount is fine from the first day.
Where it goes
A toner goes on straight after cleansing, a serum after that, a cream last.
Where to apply
Across the whole face, including around the eyes.
How to apply
Smooth it on rather than rubbing it in.
How much
On dry patches, use more of it rather than less — the driest skin is exactly where it is meant to go.
Sun
Ceramides aren’t one of the actives we flag for extra sun care. Wear sunscreen every morning anyway — that habit doesn’t depend on which ingredient you’re using.
Alongside others
It shares an evening comfortably with the rest of a routine, exfoliants and retinoids included, so it does not need one of its own.
What to look for
Look for ceramides listed alongside cholesterol and fatty acids — that blend is closest to skin's own surface lipids.
If it doesn't suit
If a ceramide product ever feels uncomfortable on your skin, switch to a different formula rather than using it less often — but if you see irritation or a rash, discontinue use.
Ceramides are naturally present in your skin's protective barrier and are well tolerated by most skin types. Discontinue use if irritation or a rash occurs.
Forms you will see it in
Ceramide essence toner
- Where it goes
- After cleansing, morning or evening
- How often
- Daily
- Strength
- Gentle
- Sun sensitivity
- None
Ceramide serum
- Where it goes
- Before moisturizer, morning or evening
- How often
- Daily
- Strength
- Gentle
- Sun sensitivity
- None
Ceramide barrier cream
- Where it goes
- As your moisturizer, morning or evening
- How often
- Daily
- Strength
- Gentle
- Sun sensitivity
- None
Using Ceramides with other ingredients
Pairs well with Ceramides
Niacinamide
Works well togetherNiacinamide supports the look and feel of the skin's moisture barrier while topical ceramides reinforce it.
Hyaluronic acid
Works well togetherHyaluronic acid draws water to the skin’s surface while ceramides help prevent that moisture from escaping.
Glycerin
Works well togetherGlycerin provides humectant moisture-binding while ceramides reinforce the look and feel of the skin's moisture barrier.
Panthenol (B5)
Works well togetherPanthenol helps skin feel softer and more comfortable while ceramides reinforce the look and feel of the skin's moisture barrier.
Squalane
Works well togetherCeramides help reinforce the look and feel of a healthy moisture barrier while squalane tops up the surface lipid film.
Petrolatum
Works well togetherCeramides help support the look and feel of the skin's moisture barrier while petrolatum seals in moisture from the surface.
Urea
Works well togetherUrea helps smooth and hydrate the skin surface while ceramides reinforce the look and feel of the skin's moisture barrier, addressing both sides of a healthier-looking complexion.
Ectoin
Works well togetherEctoin helps skin retain moisture longer while ceramides support the look and feel of the skin's moisture barrier.
Beta-Glucan
Works well togetherBeta-glucan supports a comfortable feel while ceramides help skin look and feel more resilient.
Centella asiatica
Works well togetherTogether they support the look and feel of the skin's moisture barrier for a smoother, more comfortable-looking surface.
Azulene
Works well togetherAzulene soothes while ceramides support the skin's lipid barrier.
What not to use with Ceramides
Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Ceramides — check the label of anything not covered here.
Who should avoid Ceramides?#
Six situations change whether Ceramides suits your skin right now. Each one is either a reason to skip it, a reason to go slowly, or nothing to watch for.
- Maternity & Nursing
- No caution
- Fragile or Sensitive
- No caution
- Recent Facial or Laser
- No caution
- Prone to Redness
- No caution
- Dry or Itchy Patches
- No caution
- Recent Shave or Wax
- No caution
Cosmetic strength limits for Ceramides where you live#
| Region | Most a cosmetic may contain | |
|---|---|---|
| No explicit cap | ||
The FDA restricts a short list of ingredients and sets no general strength ceiling on the rest. A figure marked "guidance, not law" is the Cosmetic Ingredient Review panel's recommendation. 21 CFR part 700, subpart B — Requirements for Specific Cosmetic Products (FDA) | ||
| No explicit cap | ||
One list does the work — Health Canada's Hotlist of prohibited and restricted cosmetic ingredients. | ||
| No explicit cap | ||
The Cosmetics Regulation's annexes, consolidated to 1 May 2026. A figure marked "guidance, not law" comes from the EU's cosmetic safety committee rather than from the annexes. | ||
| No explicit cap | ||
Great Britain kept the annexes as its own law and updates them only when it chooses; Northern Ireland follows the live EU Regulation, which is why some rows read differently for each. Regulation (EC) No 1223/2009 as it applies in Great Britain · Regulation (EC) No 1223/2009, Annexes II–VI | ||
| No explicit cap | ||
India writes its own standard, aligned to the European rules as they stood in 2012. Mandatory since 9 February 2026. IS 4707 (Part 2):2025 — restricted and prohibited cosmetic ingredients · IS 4707 (Part 3):2025 — preservatives · Cosmetics Rules, 2020, Ninth Schedule | ||
| No explicit cap | ||
ANVISA rewrote its restricted list in June 2026, and a companion act amended the prohibited list at the same time. RDC 1.029/2026 — restricted ingredients · RDC 529/2021 — prohibited ingredients, as amended by RDC 1.030/2026 · RDC 528/2021 — preservatives | ||
| No explicit cap | ||
Japan's cosmetics standard keeps drug ingredients out of cosmetics, so most of its figures sit in the ministry's list of the ones a cosmetic may still contain. Cosmetics Standards (化粧品基準), Ministry of Health, Labour and Welfare · Cosmetics Standards — the ministry's own English translation · Drug ingredients permitted in cosmetics — 2007 notification | ||
| No explicit cap | ||
One MFDS regulation carries both the prohibited list and the restricted list, in force 18 March 2026. Sunscreens and a few other categories are cleared product by product instead. Regulation on Safety Standards for Cosmetics (MFDS Notification 2026-19) · Regulation on the Review of Functional Cosmetics (MFDS Notification 2025-88) | ||
| No explicit cap | ||
Kenya's standard applies the EU annexes as they stand rather than copying them, so its ingredient limits are the EU's — including the 2024 additions. A figure marked "guidance, not law" sits outside the annexes and does not carry over. KS EAS 377-1, -2 and -3:2022 — cosmetics safety requirements, published by KEBS · Regulation (EC) No 1223/2009, Annexes II–VI | ||
| No explicit cap | ||
Namibia sets no ingredient limits at all. Its cosmetic rule is a single line requiring a product to be free of any harmful ingredient. Foodstuffs, Cosmetics and Disinfectants Ordinance 18 of 1979, and the regulations under it | ||
| No explicit cap | ||
Ukraine's own transposition of the EU annexes, as they stood before the 2024 additions, fully in force since 3 August 2026. A further revision is due on 1 February 2027. Technical Regulation on cosmetic products — Cabinet Resolution No. 65 of 20 January 2021 | ||
| No explicit cap | ||
Georgia has no cosmetics rulebook — its register of technical regulations carries no cosmetics entry — so only the general product-safety duty applies. | ||
| No explicit cap | ||
Australia writes no cosmetic ingredient list. A figure here is the point at which a substance becomes a medicine or a scheduled substance carrying Caution labeling, so its numbers sit well above other markets'. Poisons Standard — June 2026 · Therapeutic Goods (Excluded Goods) Determination 2018 | ||
| No explicit cap | ||
The Gulf standard points at the EU annexes as amended, so its ingredient limits are the EU's. A figure marked "guidance, not law" sits outside the annexes and does not carry over. GSO 1943:2024 — Cosmetic products: safety requirements (Gulf technical regulation) · Regulation (EC) No 1223/2009, Annexes II–VI | ||
| No explicit cap | ||
The Gulf standard points at the EU annexes as amended, so its ingredient limits are the EU's. A figure marked "guidance, not law" sits outside the annexes and does not carry over. GSO 1943:2024 — Cosmetic products: safety requirements (Gulf technical regulation) · Regulation (EC) No 1223/2009, Annexes II–VI | ||
| No explicit cap | ||
Hong Kong writes no cosmetics rulebook. Its Poisons List (Cap. 138A, Schedule 10) decides which substances may be sold only as medicines, and general safety is judged case by case against whichever overseas standard the enforcer considers reasonable. Pharmacy and Poisons Regulations (Cap. 138A), Schedule 10 — the poisons list · Pharmacy and Poisons Board — Guidance Notes on classifying pharmaceutical products, April 2026 | ||
| No explicit cap | ||
Singapore writes the ASEAN annexes into its own schedule, and its regulator tells companies to check the current ASEAN release as well — which is why a figure here can read "guidance, not law". Health Products (Cosmetic Products — ASEAN Cosmetic Directive) Regulations 2007, Third Schedule · ASEAN Cosmetic Directive annexes — release 2026-1, 22 June 2026 | ||
| No explicit cap | ||
Brunei carries the 2007 ASEAN annexes in its own schedule and has not updated them since, so it reads differently from Singapore on several ingredients. Medicines (Cosmetic Products) Regulations (Cap. 285 Rg 1), Schedule 1 — revised edition 2024 | ||
| No explicit cap | ||
Jordan's cosmetic rules defer to "the approved references" and name none of them, so there is no Jordanian figure to read. The only number in the instrument governs the ingredient list on the pack. JFDA instructions on cosmetics and pharmaceutical cosmetics, 2026 | ||
| No explicit cap | ||
Trinidad and Tobago has had the power to set cosmetic standards since 1960 and has never used it. The regulations made under the Act cover food and drugs, with no cosmetics part; what binds is the Act's general rule against selling a cosmetic that may injure the user. Food and Drugs Act, Chap. 30:01 · Food and Drugs Regulations | ||
No cosmetic regulator in the 20 markets above sets a maximum strength for ceramides. That is the state of the rules, not a signal to use more: how much goes into a product is the formulator's decision.
Open a market to see the rulebook its figure comes from. Those notes describe each market's own rules as we read them, current to August 24, 2026; the linked documents are the authority, and nothing here is legal advice.
Sample products with Ceramides#
A few well-known products, not a full list — product names are each brand's own. We don't sell them — the shop prices them in US dollars and ships from Hong Kong, so delivery and duties come on top. It may not ship everywhere.
We may earn a small commission when you buy through these links.
Toners · 6
TonymolyWonder Ceramide Mochi Toner - 300ml$8.88
APLBHyaluronic Acid Ceramide HA B5 Facial Toner - 160ml$9.80Also on YesStyle
THE FACE SHOPRice & Ceramide Moisturizing Toner - 150ml$10.80
FULLYRice Ceramide Essence Toner - 250ml$17.39Also on Stylevana
ByWishtrendGreen Tea & Ceramide Calming Toner Pad - 190 ml/70 Pads$17.50Also on Stylevana
beplainMilk Ceramide Moisturizing Toner - 150ml$20.00Also on YesStyleSerums · 10
APLBHyaluronic Acid Ceramide HA B5 Ampoule Serum - 40ml$9.80Also on YesStyle
ILLIYOONCeramide Ato Concentrate Cream - 75ml$10.39
AMPLE:NCeramide Shot Ampoule - 30ml$12.74
BaleaVital+ Ceramide Serum - 30ml$14.04
AMPLE:NHyper Shot Ceramide Ampoule - 50ml$15.22Also on YesStyle
FABYOUCeramide Panthenol Barrier Support Serum - 50ml$15.69
ByWishtrendMatcha & Ceramide Milky Serum - 30ml$19.60Also on Stylevana
Elizabeth ArdenAdvanced Ceramide Capsules Daily Youth Restoring Serum - 30ea$20.32
ANUA7 Rice Ceramide Hydrating Barrier Serum - 50ml$22.00Also on YesStyle
VTRice Ceramide Serum - 30ml$24.19Also on YesStyleMoisturizers · 14
APLBHyaluronic Acid Ceramide HA B5 Facial Cream - 55ml$9.80Also on YesStyle
Holika HolikaGood Cera Super Ceramide Emulsion - 130ml$12.00
NardMild Deep Moisture Ceramide Cream - 160ml$13.99
Purito SEOULLuminous Ceramide Moisturizer - 100ml$16.03Also on YesStyle
haruharu wonderBlack Rice 5 Ceramide Barrier Moisturizing Cream - 50ml$16.80Also on YesStyle
medicubeHyaluronic Ceramide Jelly Cream - 50ml$16.90Also on YesStyle
ByWishtrendGreen Tea & Ceramide Barrier Cream - 50g$17.50Also on Stylevana
COSRXThe Ceramide Skin Barrier Moisturizer - 80ml$18.40Also on YesStyle
ANUA3 Ceramide Panthenol Moisture Barrier Cream - 100ml$20.00Also on YesStyle
TOCOBOMulti Ceramide Cream - 50ml$20.80Also on Stylevana
VTRice Ceramide Capsule Cream - 50ml$21.22Also on YesStyle
make p:remRice Liposome Ceramide Barrier Cream - 50ml$24.00Also on YesStyle
Dr. Jart+Ceramidin Skin Barrier Moisturizing Cream - 50ml$30.48Also on YesStyle
SUNGBOON EDITORDeep Collagen 7GF Ceramide Advanced Barrier Night Cream - 50ml$35.00Also on YesStyleAlready have one? Check how it fits your skin with Pick.
Common questions about Ceramides#
What is Ceramides?
- The lipids skin makes for itself, topped back up on the surface — it is what keeps skin from feeling tight, dry and rough.
What else is Ceramides called?
- On a label you may see Ceramide, Ceramide NP, Ceramide AP and Ceramide EOP.
When should you apply Ceramides?
- Morning or evening.
Which form of Ceramides should you use?
- Ceramide essence toner — after cleansing, morning or evening, daily. Ceramide serum — before moisturizer, morning or evening, daily. Ceramide barrier cream — as your moisturizer, morning or evening, daily.
How often can you use Ceramides?
- Daily.
Where do you apply Ceramides?
- All over the face. Keep it away from your eyes and lips.
Can you use Ceramides around the eyes?
- Yes. Ceramides goes all over the face, the skin around the eyes included — keep it out of your eyes and off your lips.
Does Ceramides make skin more sensitive to the sun?
- No. Ceramides is not flagged as increasing sun sensitivity.
What should you not use with Ceramides?
- Nothing flagged. None of the ingredients this wiki covers needs to be kept apart from Ceramides — check the label of anything not covered here.
Is there a cosmetic limit for Ceramides?
- No. No cosmetic regulator in the United States, Canada, the European Union or Great Britain sets a maximum strength for it. That is a limit on the rules, not a signal to use more.
Related ingredients#
How we check this#
Everything on this page traces to the sources listed below — regulators' own publications and published studies. Where the evidence does not answer a question, it is left unanswered.
Our review is AI-assisted and is not a named expert's opinion. Last reviewed August 4, 2026.
Think something here is out of date or wrong? Email us at wiki@skinintelligence.ai with your reasoning and where you read it. We read what people send, and we update the page when the sources support it.
Regulators and official bodies · 8
- S1Cosmetic Ingredient Review Expert Panel. Safety Assessment of Ceramides as Used in Cosmetics — Final Report, release date 6 April 2015, panel meeting 16–17 March 2015.
- S2US FDA, Center for Devices and Radiological Health. 510(k) Summary and Indications for Use statement, K052643 — EPICERAM® Skin Barrier Emulsion, Ceragenix Corporation; substantially equivalent, 11 April 2006. Classification name "Dressing, Wound & Burn, Hydrogel w/Drug or Biologic"; product code FRO; Prescription Use.
- S3NICE. Atopic eczema in under 12s: diagnosis and management (CG57), Recommendations §1.5.1.2 and §1.5.1.4–1.5.1.11 [2007, amended 2023].
- S4Sidbury R, Alikhan A, Bercovitch L, Cohen DE, Darr JM, Drucker AM, Eichenfield LF, Frazer-Green L, Paller AS, Schwarzenberger K, Silverberg JI, Singh AM, Wu PA, Davis DMR. Guidelines of care for the management of atopic dermatitis in adults with topical therapies. J Am Acad Dermatol 2023;89(1):e1–e20. PMID 36641009 · doi:10.1016/j.jaad.2022.12.029.
- S5Regulation (EC) No 1223/2009 on cosmetic products, consolidated text of 01.09.2025 (CELEX 02009R1223-20250901), Annex II.
- S6Health Canada. Cosmetic Ingredient Hotlist: Prohibited and Restricted Ingredients — substance list.
- S7US FDA. Prohibited & Restricted Ingredients in Cosmetics.
- S8UK Government. Making cosmetic products available to consumers in Great Britain; Regulation 1223/2009 and the Cosmetic Products Enforcement Regulations 2013: Great Britain.
Studies and references · 34
- S9Gwon DH, Choi HK, Lee EO, Hong SK, Park CS, Kim JW, Liu KH. Impact of Ceramide Acyl Chain Length on Human Skin Barrier Recovery and Hydration. J Cosmet Dermatol 2026. PMID 41814138 · doi:10.1111/jocd.70795.
- S10Berkers T, Visscher D, Gooris GS, Bouwstra JA. Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin. Pharm Res 2018. PMID 29411158 · PMC5801391 · doi:10.1007/s11095-017-2288-y.
- S11Man MQ, Feingold KR, Thornfeldt CR, Elias PM. Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol 1996;106(5):1096–101. PMID 8618046 · doi:10.1111/1523-1747.ep12340135.
- S12Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol 1997;37(3 Pt 1):403–8. PMID 9308554.
- S13Andrew PV, Williams SF, Brown K, Chittock J, Pinnock A, Poyner A, Cork MJ, Danby SG. Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis. Br J Dermatol 2025;193(4):729–740. PMID 40408261 · doi:10.1093/bjd/ljaf200.
- S14Nugroho WT, Sawitri S, Astindari A, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol 2023. PMID 37151263 · PMC10162745 · doi:10.4103/ijd.ijd_991_22.
- S15Ho VPY, Ma E, Liew HM, Ng MSY, Koh MJA. Comparing the Potential for Irritation of a Ceramide-Based Moisturizer with a Urea-Based Moisturizer for Pediatric Atopic Dermatitis. Dermatol Ther (Heidelb) 2020. PMID 32372387 · PMC7367988 · doi:10.1007/s13555-020-00388-6.
- S16Yajima J. Allergic contact dermatitis due to hydrophilized ceramide. Contact Dermatitis 2002;47(4):245. PMID 12492536 · doi:10.1034/j.1600-0536.2002.470418_2.x.
- S17Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol 2008;47(8). PMID 18717861 · doi:10.1111/j.1365-4632.2008.03687.x.
- S18Lueangarun S, Tragulplaingam P, Sugkraroek S, Tempark T. The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment. Dermatol Ther 2019;32(6):e13090. PMID 31585489 · doi:10.1111/dth.13090.
- S19Draelos ZD, Baalbaki NH, Raab S, Colón G. The Effect of a Ceramide-Containing Product on Stratum Corneum Lipid Levels in Dry Legs. J Drugs Dermatol 2020;19(4):372–376. PMID 32272513 · doi:10.36849/JDD.2020.4796.
- S20Draelos ZD, Baalbaki N, Colon G, Dreno B. Ceramide-Containing Adjunctive Skin Care for Skin Barrier Restoration During Acne Vulgaris Treatment. J Drugs Dermatol 2023;22(6):554–558. PMID 37276158 · doi:10.36849/JDD.7142.
- S21Tempark T, Shem A, Lueangarun S. Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial. J Cosmet Dermatol 2024;23(5):1758–1765. PMID 38299457 · doi:10.1111/jocd.16212.
- S22Schorr ES, Sidou F, Kerrouche N. Adjunctive use of a facial moisturizer SPF 30 containing ceramide precursor improves tolerability of topical tretinoin 0.05%: a randomized, investigator-blinded, split-face study. J Drugs Dermatol 2012;11(9):1104–7. PMID 23135655.
- S23Baldwin H, Alexis AF, Andriessen A, Berson DS, Farris P, Harper J, Lain E, Marchbein S, Stein Gold L, Tan J. Evidence of Barrier Deficiency in Rosacea and the Importance of Integrating OTC Skincare Products into Treatment Regimens. J Drugs Dermatol 2021;20(4):384–392. PMID 33852244 · doi:10.36849/JDD.2021.5861.
- S24Xia Y, Lyu Y, Yang J, He X, Yi Y, Liu J, Zhu Z, Du Z, Chen Y, Ai Y. Effects of a Ceramide-Containing Glycinate-Based Cleanser on the Condition of Oily Skin and Skin Post-IPL Treatments. J Cosmet Dermatol 2025. PMID 40671479 · PMC12268312 · doi:10.1111/jocd.70350.
- S25Gold M, Andriessen A, Greiner-Krüger D, Lain E, Lee S, Suh H, McDonald C, Nisticò S, Taher Z, Wang M, Brieva P. Real-World Patient Cases Using Triple Lipid-Containing Cream for Cutaneous Healing Post Laser or Microneedling Radiofrequency Treatment. J Drugs Dermatol 2024;23(9 Suppl 1):s3–14. PMID 39231086.
- S26Hamie H, Yassine R, Shoukfeh R, Turk D, Huq F, Moossavi M. A review of the efficacy of popular eye cream ingredients. Int J Womens Dermatol 2024. PMID 38873621 · PMC11175953 · doi:10.1097/JW9.0000000000000156.
- S27Spada F, Harrison IP, Barnes TM, Greive KA, Daniels D, Townley JP, Mostafa N, Fong AT, Tong PL, Shumack S. A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial. Dermatol Ther 2021;34(4):e14970. PMID 33984185 · PMC8459234 · doi:10.1111/dth.14970.
- S28Lynde CW, Andriessen A. A cohort study on a ceramide-containing cleanser and moisturizer used for atopic dermatitis. Cutis 2014;93(4):207–13. PMID 24818182.
- S29Wu Y, Wangari-Olivero J, Zhen Y. Compromised Skin Barrier and Sensitive Skin in Diverse Populations. J Drugs Dermatol 2021;20(4 Suppl):s17–s22. PMID 33852256 · doi:10.36849/JDD.2021.589c.
- S30Schachner L, Alexis A, Andriessen A, Baldwin H, Cork M, Kirsner R, Woolery-Lloyd H. The Importance of a Healthy Skin Barrier From the Cradle to the Grave Using Ceramide-Containing Cleansers and Moisturizers: A Review and Consensus. J Drugs Dermatol 2023;22(2 Suppl). PMID 36745380.
- S31Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol 2000;143(3). PMID 10971324.
- S32Rawlings AV, Davies A, Carlomusto M, Pillai S, Zhang K, Kosturko R, Verdejo P, Feinberg C, Nguyen L, Chandar P. Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res 1996;288(7):383–90. PMID 8818186 · doi:10.1007/BF02507107.
- S33Fartasch M, Teal J, Menon GK. Mode of action of glycolic acid on human stratum corneum: ultrastructural and functional evaluation of the epidermal barrier. Arch Dermatol Res 1997;289(7):404–9. PMID 9248619 · doi:10.1007/s004030050212.
- S34Chon SH, Tannahill R, Yao X, Southall MD, Pappas A. Keratinocyte differentiation and upregulation of ceramide synthesis induced by an oat lipid extract via the activation of PPAR pathways. Exp Dermatol 2015;24(4):290–5. PMID 25651930 · doi:10.1111/exd.12658.
- S35Anggraeni S, Umborowati MA, Damayanti D, Endaryanto A, Prakoeswa CRS. Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers. J Basic Clin Physiol Pharmacol 2021;32(4):589–593. PMID 34214362 · doi:10.1515/jbcpp-2020-0510.
- S36Danby SG, Brown K, Higgs-Bayliss T, Chittock J, Albenali L, Cork MJ. The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin. Skin Pharmacol Physiol 2016;29(3):135–47. PMID 27251427 · doi:10.1159/000445955.
- S37Vender RB, Andriessen A, Barankin B, Freiman A, Kyritsis D, Mistos LM, Salsberg J, Amar L. Cohort Using a Ceramides Containing Cleanser and Cream With Salicylic Acid for Dry, Flaking, and Scaling Skin Conditions. J Drugs Dermatol 2019;18(1):80–85. PMID 30681802.
- S38Del Rosso JQ. Ceramide- and Keratolytic-containing Body Cleanser and Cream Application in Patients with Psoriasis: Outcomes from a Consumer Usage Study. J Clin Aesthet Dermatol 2019;12(7). PMID 31531158.
- S39Tsuchiya S, Ichioka S, Sekiya N, Tajima S, Iwasaki T, Numata S. The effect of a hydrocolloid dressing containing ceramide-2 on split-thickness wounds in a laser-induced erosion model. Adv Skin Wound Care 2013;26(5):224–9. PMID 23591096 · doi:10.1097/01.ASW.0000428952.00149.77.
- S40Su Z, Zheng Y, Yi J, Lai W, Ye C. The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study. J Cosmet Dermatol 2025. PMID 40682399 · PMC12274965 · doi:10.1111/jocd.70324.
- S41National Rosacea Society. Prescription and OTC Products Can Work Together to Repair Skin Barrier Damage. Rosacea Review, Spring 2023. Treated as Tier 3 — the NRS is a Tier 1 body, but this is a patient newsletter summarising S23, and § Tier definitions holds that "a body's patient leaflet is not its guidance".
- S42Li M, Lynde C, Sibley C, Bernstein SC, Mathieu S, Guenther L, Dayeh NR, Tan J. A Multicentre Evaluation of a Ceramide-Containing Hydrating Cream-to-Foam Cleanser and Facial Moisturizing Lotion for Improving Topical Treatment Tolerability in Facial Acne. J Cutan Med Surg 2025;29(1_suppl):3S–13S. PMID 39835475 · doi:10.1177/12034754241304729.



